Correlation of Surfactant Protein-D (SP-D) Serum Levels with ARDS Severity and Mortality in Covid-19 Patients in Indonesia

Authors

  • Alexander Agustama Anesthesiology and Intensive Care Department, Faculty of Medicine, Universitas Airlangga, Surabaya 60286
  • Anna Surgean Veterini Anesthesiology and Intensive Care Department, Faculty of Medicine, Universitas Airlangga, Surabaya 60286
  • Arie Utariani Anesthesiology and Intensive Care Department, Faculty of Medicine, Universitas Airlangga, Surabaya 60286

DOI:

https://doi.org/10.5644/ama2006-124.366

Keywords:

Surfactant Protein-D, ARDS, Severity, Mortality, COVID-19

Abstract

Objective. The purpose of this research was to investigate the correlation between serum levels of surfactant protein-D (SPD) with acute respiratory distress syndrome (ARDS) severity and mortality in COVID-19. Materials and Method. This was a prospective cohort research study that included 76 patients in the period from July to October 2020. SP-D serum levels were taken upon admission to the hospital, the diagnosis of ARDS and its gradewere confirmed according to the WHO criteria, and then patients were observed for 28-day mortality.

Results. The mean SP-D serum levels from 76 patients were 39.33 ng/ml (SD±31.884 ng/ml). The statistical analysis showed that there was a significant correlation between SP-D serum levels and the severity of ARDS upon admission to the hospital (P=0.04, Spearman’s rank correlation coefficient (rs)=0.26), but the correlation between serum levels of SP-D and mortality was not statistically significant (P=0.89; rs=-0.016).

Conclusion. SP-D serum levels had a significant but weak correlation with ARDS severity, but were not significant for mortality.

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Published

2022-12-16

How to Cite

Agustama, A., Surgean Veterini, A., & Utariani, A. (2022). Correlation of Surfactant Protein-D (SP-D) Serum Levels with ARDS Severity and Mortality in Covid-19 Patients in Indonesia. Acta Medica Academica, 51(1), 21–28. https://doi.org/10.5644/ama2006-124.366

Issue

Section

Clinical Medicine

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