Hemodvnamic and Resperatory Responses of Dogs to Hemorrhage After Treatment With Dihydroergotoxine and Naloxone
DOI:
https://doi.org/10.5644/Radovi.392Keywords:
hemorrhagic shock, dogs, opiate receptor blockade, alpha adreneigic receptor blockadeAbstract
The endogenous opiate receptor antagonist (naloxone, NAL) and alpha-adrenergic receptor antagonist (dihydroergotoxine, DHETX) were infused separately or simultaneously in dogs to determine their effects in hemonhagic shock. Mean arterial pressure, heart rate, electrocardiogram, respiratory rate, haematocrit and plasma protein concentration were measured during sustained posthemorrhagic hypotension (180 min, 40 mmHg) in 22 dogs. Animals were divided into four groups: DHETX-treated (n=6), NAL-treated (n=5), DHETX+NAL-treated (n=5), and SAL (saline)-treated (control group, n=6). The treatment was performed before bleeding. After 3 hours of posthemorrhagic hypotension, ali shed blood was returned to the dogs, and animals passed through a postretrasfusion period for 60 min. The animals which survived experimental procedure were observed in next 24 hours. Under the present experimental conditions, prophylactic administration of DHETX had better effects on preservation of parameters measured and survival of dogs than NAL, while DHETX+NAL treatment had the worst effects (no one dog survived).
References
Faden AI, Holaday JW: Opiate antagoniste: A role in the treatment of hypovolemic shock. Science 205:317-318,1979.
Molina PE: Opiate modulation of hemodynamic, hormonal, and cytokine responses to hemorrhage. Shock 15:471-478,2001.
Curtis MT, Lefer AM: Protective actions of naloxone in hemorrhagic shock. Am J Physiol 239 (8):H416-H421,1980.
Vargish T, Beamer KC, Daly T, Riggs TR: Morphine sulfate depression of cardiac function is attenuated by opiate receptor antagonism with naloxone. Circ Shock 23:189-195,1987.
Brown DF, Biirr RE: Naloxone fails to reverse hemorrhagic hypotension. Am J Physiol 25 l:H468-H470,1986.
Feuerstein G, Siren AL: Efifect of naloxone and morphine on survival of conscious rate after hemorrhage. Circ Shock 19:293-300,1986.
Feuerstein G, Siren AL Goldstein DS, Johnson AK, Zerbe RL: Effect of morphine on the hemodynamic and neuroendocrine responses to hemonhage in conscious rats. Circ Shock 27:219-235,1989.
Vargish T, Reynolds DG, Gurll NJ, Lechner RB, Holaday JE, Faden AI: Naloxone reversal of hypovolemic shock in dogs. Circ Shock 7:31-38,1980.
Gu H, Gaugl JF, Barron BA, Caffirey JL: Naloxone enhances cardiaac contractile responses to epinephrine without altering epinephrine uptake from plasma. Circ Shock 32:257-271,1990.
Krnic J, Hamamdžac M, Sandor F, Duzic E, Magazinovic V: The effects of phenoxybenzamine on some hemodynamic parameters in experimental hemonhagic shock in conscious dogs. lugoslav. Physiol. Pharmacol. Acta 19:101-104,1983.
Krnic J, Kamamdžic M, Duzic E, Magazinovic V: The effects of hemorrhage and treatment with phenoxybenzamine on liver and pancreatic blood flow in anesthetized dogs. lugoslav. Physiol. Pharmacol. Acta 21 (Suppl. 4): 147-148,1985.
Krnic J, Hamamdžšc M, Duzic E, Magazinovic V: Liver blood flow during hemorrhagic shock in the dog treated with phenoxybenzamine. Acta Physiologica Hungarica 70(l):31-35,1987.
Beamer KC, Daly T, Vargish T: Late administration of methylprednisolone does not enhance naloxone effect in hypovolemic shock. Circ Shock 19:221-230,1986.
Sušic D, Ðordevic N, Kentera D: Hemodynamic effects of ergot derivatives: ergosine, dihydroergotoksine and dihydroergotamine. lugoslav. Physiol. Pharmacol. Acta21(l):67-75,1985.
15. Markstein R: HydergineR: friteraction avec les systemes de neurotransmission dans le systeme nerveux Central. J. Pharmacol. 16(m): 1-19,1985.
Markstein R, Closse A, Frick W: Interaction of ergot alkaloids and their combination (co-dergocrine) with alpha-adrenoceptors in the CNS. European J. Pharmacol. 93:159-168,1983.
Roquebert J, Demichel P: Alpha-adrenergic agonist and antagonist activity of dihydroergotoxine in rats. J. Pharm. Phaimacol. 37:415-420, 1985.
Coppi G: Dihydroergocristine. A review of pharmacology and toxicology. Arzneimittelforschung 42(11 A): 1381-1390,1992.
Goldstein M, Lew JY, Hata F, Lieberman A: Binding interactions of ergot alkaloides with monoaminergic receptors in the brain. Gerontology 24(Suppl. l):76-85,1978.
Miiller-Schvveinitzer E: Actions of co-dergocrine mesylate and its componerits at vascular smooth muscle. Naunyn-Schmiedeb. Arch. Pharmacol. 318:225-233,1982.
White JM, Irvine RJ: Mechanisms of fatal opioid overdose. Addiction 94(7):961-972,1999.
Schlenker EH, Inamdar SR: Effects of naloxone on oxygen consuption and ventilation in awake golden Syrian hamsters. Physiol. Behav. 57:655-658,1995.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Muhidin Hamamdžić, Eva Pašić Juhas, Josip Krnić, Aida Hodžić, Mirsad Kadrić
This work is licensed under a Creative Commons Attribution 4.0 International License.
