Adverse Reactions of Cyclosporinein Patients After Kidney Transplantation
DOI:
https://doi.org/10.5644/Radovi.397Keywords:
Cyclosporine, Determination, Nephrotoxicity, HapatotoxicityAbstract
Increased level of cyclosporine in whole blood leads to different severe adverse reactions causing disturbance in function of kidney as well as liver, central nervous system, increased blood pressure, gingival hipertrophy. Low doses of cyclosporine lead to HVGR (host versus graft reaction). Cyclosporine level in whole blood does not depend upon dose only. So the level of cyclosporine has to be determined regularly to avoid either severe adverse reactions of the drug or HVGR.
In the present study we analysed cyclosporine levels in 15 patients after kidney transplantation. Cyclosporine levels were determined by fluorescence polarization immuno assay, and the monoclonal whole blood was carried out by analizer ABBOT - TDX. In these patients the cyclosporine level determinants were performed six times during three months. In intervals of 15 days, at the exactly same time, we followed the parameters determining the kidney and liver functions : creatinin, ALT(Alanin aminotranssferasis), AST(Aspartat aminotranssferasis), serum concentrations of bilirubin, and ultrasound diagnostics of kidney and liver). The results of our study have shown that frequent monitoring of cyclosporine concentrations in whole blood in patients with transplanted kidney is extremely important It is the way how to maintain the cyclosporine levels in whole blood in the recommended interval between 100 and 300 ng/ml. By doing it the adverse drug reactions of cyclosporine in our study were reduced to a minimal level.
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