Results From Our Study of Periodontal Disease Pathogenesis
DOI:
https://doi.org/10.5644/Radovi.245Abstract
Some of the mechanisms of periodontal disease pathogenesis have been studied for a longer period at the Clinic of Mouth Diseases, Faculty of Stomatology in Skopje. Our investigation concept was based on evaluation of several parameters: gingival immune response, salivary enzyme activity, connective tissue complex alterations, the role of oligoelements in cellular metabolism.
In parotid saliva we found IgA significantly increased while absence of IgG and IgM. In the gingival biotic material treated by the direct immunofluorescence method by Saint-Marie we found IgG, IgA and IgE in lymphocytes and plasma cells, basement membrane and cell membrane, mostly in the terminal stage of the disease.
Evaluation of salivary alkaline and acidic phosphatase, glutamate pyruvate transaminase, glutamate oxalate transaminase and lactate dehydrogenase were significantly increased in relation to the stage of periodontal disease and its clinical manifestation.
Labelled amino acids: hydroxyproline, proline, glycine, serin allanine, arginine, lysine, methionine and histidine suggested to decreasment of incorporation of amino acids, especially of proline, hydroxyproline, glycine and serine in correlation to the clinical evolution of periodontal disease, by rule.
Similar results were achieved in experimentally induced periodontal disease in Wistar rats by submucous application pf 0.1 ml hyaluronidase solution.
Considering the bio-effects of oligoelements we determined the concentrations of calcium, magnesium, iron, copper, zine, manganese in serum, saliva, gingiva alveolar bone and urine in patients with periodontal disease. Seral concentrations of all oligoelements did not reveal significant differences; in saliva, only calcium and iron had higher values, in gingiva they were significantly high, in alveolar bone only calcium and zine revealed lower significant increase, while in urine, increasement was significantly emphasised, except for copper.
Our investigation supports the summarised conclusion that primary metabolic disorders of the connective tissue complex play a very important role in the pathogenesis of periodontal disease.
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Copyright (c) 2026 Blagorodna Lazarevska, Vangel Dimitrovski, Marija Nakova, Metodi Simonovski, Zlatanka Nikolovska
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