Genetic Elements in Tumor Etiopathogenesis With Regard to Skin Tumors
DOI:
https://doi.org/10.5644/Radovi.259Abstract
Genetic elements in the neoplasma etiopathogenesis are reflected on the molecular, cellular and individual level. Their roles are intricately interwoven and they should not be taken isolate from each other, since individual processes occur on the cellular level and cellular processes, in turn, on the molecular level. Four groups of data are being presented, indicating the role of deficiency of immunological factors in the neoplasma etiopathogenesis.
1. In 94 patients with various skin and other neoplasmas, the State of delayed immune reaction has been examined. The following tests have been used for the evaluation of this type of immune reaction: DNCB, intradermal tests with PPD and trichophytin. 56 patients were sensibilized to DNCB (59,6%); two of them had metastases. 38 patients (40,4%) could not be sensibilized; 6 of them had metastases. 4 patients from the latter and 5 from the former group did not react to PPD and trichophyton. Two females with basocellular naevus syndrome were sensibilised to DNCB.
The age of patients sensible to DNCB was about 57,6 ± 3,1 and the age of patients insensible to DNCB was 71,4 ± 3,1. The difference is statistically significant (p = 0,01).
2. There was no positive correlation in the histological picture between the possibility of sensibilization to DNCB and the intensity of inflammatory reaction around the tumour.
3. Two patients with autosomal recessively inherited Xeroderma pigmentosum (a brother and a sister) could not be sensibilized to DNCB. Intradermal treatment with trichophytin and staphylovaccine gave negative results. It is therefore probable that the early occurrence of skin tumour can be attributed, in addition to the reparation defect of damaged DNA, to the genetically determined immune reaction defect of the delayed type.
4. The defect of immunological control also existed in the case of a patient suffering from the autosomal recessively inherited Werner syndrome: the lymphocyte transformation test and the number of T-lymphocytes were reduced, the number of B-lymphocytes remaining normal. PPD and trichophytin gave negative results. It is known that in 10% of cases of Werner syndrome there are solid neoplasmas of different organs.
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