Electron Paramagnetic Resonance and Its Possible Use in the Pharmacological and Toxicological Studies of Drugs
DOI:
https://doi.org/10.5644/Radovi.262Abstract
Electron paramagnetic resonance is a spectroscopic method which can be also used in the study of different pharmacological and toxicological properties of drugs, such as drug resorption, distribution, excretion and metabolism. Further, various effects mediated via receptors or enzymes and effects not mediated via receptors, i. e. nonspecific effects on membrane due to physical and/or Chemical properties of drug can be investigated. Some essential results of our own studies concerning the properties of acetylcholinesterase and cholinoreceptor are presented. Beside this, the influence of cholinergic substances on membrane fluidity is described.
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