Editor-in-Chief: Husref Tahirović EDITORIAL CONTACT INFORMATION Acta Medica Academica Academy of Sciences and Arts of Bosnia and Herzegovina Bistrik 7, 71000 Sarajevo, Bosnia and Herzegovina Tel.: + 387 33 560 718; Fax.: + 387 33 560 703 Contact Person: Nerma Tanović; E-mail: amabih@anubih.ba This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
Academy of Sciences and Arts of Bosnia and Herzegovina
Surgical Re-Resection for Isolated Local Recurrence of Pancreatic Cancer: A CaseSeries of 3 Patients and Literature Review
Objective. This retrospective case series study aims to assess the clinical role of surgical re-resection for isolated local recurrence of pancreatic cancer, integrating detailed case presentations with current evidence to clarify patient selection criteria, operative feasibility, and oncologic outcomes. Case Presentations. We present three patients with locally recurrent pancreatic cancer who underwent repeat pancreatic resection. Patient 1, who previously underwent distal pancreatectomy for an Intraductal Papillary Mucinous Neoplasm (IPMN)-associated adenocarcinoma, developed a new pancreatic head lesion three years later and under- went pylorus-preserving pancreaticoduodenectomy; histopathology confirmed a small invasive IPMN, and the patient remains alive 8 years after the initial diagnosis and 5 years after the reoperation. Patient 2, who had previously undergone Pylorus-Preserving Pancreaticoduodenectomy for distal bile duct adenocarcinoma, developed recurrent disease in the pancreatic body and tail three years later. He underwent distal pancreatectomy but developed liver recurrence due to hematogenous metastasis one month postoperatively and succumbed 6 months later from generalized widespread disease. Patient 3, who previously un- derwent a Whipple procedure for IPMN-associated adenocarcinoma, developed a recurrent mass at the pancreatojejunostomy five years later and underwent distal pancreatectomy, with an uneventful recovery. Conclusion. Our findings suggest that repeat pancreatic resection may be feasible in carefully selected patients with isolated local recurrence, potentially offering a survival benefit. Strict selection criteria, including the absence of distant metastases, good performance status, and technically resect- able disease, appear essential to optimize outcomes, supporting the consideration of surgical re-resection as an option within a multidisciplinary management framework.
Copyright (c) 2025 Spiros Delis, Nikolaos Taprantzis, Dimosthenis Chrysikos, Amir Shihada, Theodore Troupis https://creativecommons.org/licenses/by/4.0/
Appendiceal Neuroendocrine Tumors in Children and Adolescents
Objective. To synthesize current evidence on the diagnosis, histopathological evaluation, clinical features, management, and follow-up of appendiceal neuroendocrine tumors (aNETs) in children and adolescents, and to outline key differences from their adult counterparts. Background. Pediatric aNETs are rare gastrointestinal neoplasms that typically exhibit an indolent clinical course with minimal risk of recurrence or metastasis. Their biological and prognostic features differ from those in adults, limiting the applicability of adult-derived guidelines in children. Methods. A mini-review of the current literature was conducted, focusing on the epidemiology, clinical presentation, diagnostic workup, key pathological features, surgical management, and follow-up strategies for pediatric aNETs. Discussion. Contemporary evidence supports a de-escalated, risk-adapted approach to management, with simple appendectomy being curative in most cases. Multidisciplinary Team (MDT) discussions remain critical for atypical or borderline cases requiring individualized decision-making. Differences from adult aNETs highlight the need for pediatric-specific clinical approaches. Conclusion. Early recognition, accurate histopathologic evaluation, and tailored surgical management are essential to optimize outcomes for children and adolescents with aNETs.
Copyright (c) 2025 Jelena Roganović, Calogero Virgone https://creativecommons.org/licenses/by/4.0/
Epidermal Biology in Relation to Skin Diseases
Copyright (c) 2026 Hermann Pinkus https://creativecommons.org/licenses/by/4.0/
Influence of Lysozymes Upon the Antigenic Reactivity of Treponema Pallidum in the Fluorescent Antibody Test (FTA)
Comparative investigations have been carried out in respect of the antigenic reactivity of T. pallidum in FTAs and FTA-ABS test under influence of lysozyme. The analysis was performed on 30 sera which were TPI, FTA200 and STS negative. It could be demonstrated by this investigation, that suspensions of Treponemes treated with lysozyme in the FTAs and FTA-ABS test acquire the ability to bind the group specific antibodies and to produce more biologic false positive results than suspensions without addition of lysozyme. It could be further shown that the effect of lysozyme on the antigenic reactivity of Treponemes depends also on the age of the respective Treponeme suspension. In fresh suspensions the effect of lysozyme is more intensive than in the older one.
Copyright (c) 2026 Mira Nadaždin, Ernest I. Grin https://creativecommons.org/licenses/by/4.0/
Physiological Role of the Immune Reaction
There are experimental data which suggest that the immune reaction should have a physiological role, the usual immune response being only an expression of the same phenomenon resulting upon the inoculation of unfamiliar antigenic molecules. Besides experimental data the attention should be paid to the well-known “instructive” and “selective” theories of the immunological reaction. If »instruction« of immunologically competent cells would play a predominant role in the immunological response, then the cells should be omnipotent. This would imply in responsible cells occurring either change or depression of pacific gene(s) upon inoculation of an unfamiliar antigen. Whatsoever the mechanisms of changes in stimulated cells are, the ability of cells to accept all kinds of antigens could be explained by assuming the existence of a great many of different antigen receptors being scattered over the cell membrane. This way of thinking conduces to the study of receptors for proteins (also protein hormones) on the surface of cell membrane. Differentiated cells have specific receptors on the surface of their cell membranes, and there is no reason to call in question this quality in immunologically competent cells. These postulates are in the ground of the Burnet’s clonal selection theory. Receptors as well as antigens are expressions of the gene’s activity in cells. Thereafter it appears conceivable that the cells displaying the same function and producing the same product possess common antigens even if they originate from different species (organ-specific antigens). Despite the existence of organ-specific antigens the autoagressive diseases are however infrequent. This phenomenon of autoagressive diseases belongs to the problem of “self-not self-recognition”, or even “self-tolerance”. It seems that the tolerance of allogeneic or xenogeneic antigens in chimeric organisms as well as of tumour antigens in tumorous organisms belongs to the same phenomenon. There appears to be nothing for it, but to assume that organisms cover antigenic sites of “own” cells with complementary proteins (immunoglobulins, protein-hormones or other proteins). Consequently, the same should occur in chimeric animals and in tumour bearing organisms. By covering the antigenic sites of “own”, foreign or tumour cells they become inaccessible to the destructive action of cellular immunity. However, these protein coats could act as integral part of cell membranes thus enabling the cells to function and to survive. Some data speak strongly in favour of the described hypothesis. Anaphylactic reaction is known to be mainly due to the reaction of immunoglobulins adsorbed on the surface of cell membranes of” shock-organ(s)”. Tanned and trypsinized erythrocytes are suitable for adsorption of proteins. Erythrocytes and polymorphonuclear leukocytes can be washed from coating immunoglobulins thus undergoing the loss of their function as well as the ability to survive. It appears interesting to note that Wistar rats displaying a high incidence of experimental allergic encephalomyelitis have in serum a low titter of complement fixating antibrain antibodies. Lewis rats show an opposite picture. Enhancement of tumour growth with complementary immunoglobulins speaks strongly in favour of the theory of the protective activity of proteins coating the specific antigenic sites of cell membranes. It has been tried to produce de-enhancement by anti-serum antibodies and cathepsins acting mostly specifically upon gamma, (and beta) globulins. Indeed, rats inoculated with Yoshida ascites sarcoma cells survived longer if injected intravenously with rabbit antiserum against rat serum or cathepsins from leukocytes of swine blood. Regarding to cellular immunity the best way to learn its physiological role seems to be by understanding the phenomenon lying in the ground of the hypothesis of allogeneic inhibition. This mechanism would be responsible for the elimination of all newformed cells or antigen(s) which were not suitable to be protected by coating proteins.
Copyright (c) 2026 Nikša Allegretti https://creativecommons.org/licenses/by/4.0/
It was thought necessary to present our experience with this kind of poisoning, since it is probable that new facts about the effect of a salycil ion would extend its use, and by that, the possibility of acute salicylism. On the basis of the pharmaco-dynamic characteristics of salicyltes, a physician must realize the risk of their therapeutic application as well as the length of administering them. The damage which can be caused by a salycil ion is almost as extensive as its therapeutic effect. The question of dosage and the length and rhythm of its administration (daily intake) is one to be decided upon from one patient to the next, bearing in mind the capability of a salicyl ion te accumulate in the tissue and cause sudden poisoning, especially in the dehydrated child. Acute salicylism can develop in an acute form, even following the single dose 500 mg in a dehydrated child. Poisoning in children with the prolonged taking of salicyl are more frequent, since it is a cumulative agens. Ali that influences, its resorption and elimination through the urinary tract increases risk of administration of this agens, which by the wide scope of its use seemingly harmless.
Copyright (c) 2026 Ešref Sarajlić, Nedžad Hadžimusić https://creativecommons.org/licenses/by/4.0/
The Movement of Blood Lipids in Middle-Aged Persons and Persons Older Then 60 Years With Begun and Developped Stadium of Degenerative Sclerotic Changes on Arterious Vessels
In consideration of different origin of hyperlipemia, it is necessary to indicate every hyperlipemia because of decant diagnosis and management this study and on the basis of classification of Fredrickson, our data established a mixed hyperlipemia with all patients from forty till fifty-nine years of ages. The author also had found a correlation between a mixed hyperlipemia in relation with coronaropathies. On the average all patients with sixty years of ages have the lower values of lipids in the blood. In the continuation author discussed this problem as same as the management of vasculopathies of old patients.
Copyright (c) 2026 Džemal Rezaković https://creativecommons.org/licenses/by/4.0/
Tumori pijeluma i uretera u regionima endemske nefropatije
Copyright (c) 2026 Sava Petković https://creativecommons.org/licenses/by/4.0/
In this study were reviewed the results of experiments on 580 rabbits made in order to explain the pathogenesis of the histamine shock. The reactions of blood vessels and microscopic changes were examined, the behaviour of the endothelial cells, platelets and clotting factors, morphological changes of cells and organs, the appearance of morphological equivalents of disseminated intravascular coagulation (DIC). This investigation was made in all developing phases of histamine shock and in recovery period of 5 days. By electron microscopic and interference microscopic investigation compared to their findings, we got some new information, which show us in a new light a development of the histamine shock. It is possible to conclude that primary processes are not spastic disorders of local circulation. “Lungensperre” either in lesions of capillar permeability and consequent oligemia, but they are a consequence of embolic obstruction of pulmonary capillars and capillars of the other organs as well by accumulation of agglutinated platelts, which afterwards locally become the fibrin microthrombi. Aggregation and aglutination of platelets, which later break the whole system of hemostase and produce the picture of DIC-syndroma in which is included coagulopathy of the consumption. This is provoked probably by direct influence of histamine on platelet membranes or elements of gramulomera. Microthrombotic obstruction of pulmonary capillars in histamine shock represents that real substratum of so called “Lungensperre” which existence was by physiological methods registered in the time of Dale, but nowadays is morphologically visualised. Disorder of capillar perfusion in many important organs which appears simultaneously and is provoked by above mentioned mechanism, is also a manifestation of DIC and is responsible for pass of histamine shock in irreversible phase i. e. lethal exit.
Copyright (c) 2026 Aleksandar Nikulin https://creativecommons.org/licenses/by/4.0/
Glaciofluvijalna erozija — primarni etiopatogenetski faktor čovjekove endemske strume i vezikalne hematurije goveda
Copyright (c) 2026 Josip Ježić i saradnici https://creativecommons.org/licenses/by/4.0/
Copyright (c) 2026 Vojislav Danilović https://creativecommons.org/licenses/by/4.0/
The Effect of the Drugs Acting on the Cardiovascular System on the Model-Systems of Heart and Blood Vessels
The indirect stimulation of the isolated oesophagus, urinary bladder and ductus deferens induced contraction. They were used as a model-systems. The modification of rhythmic contractions of oesophageal striated muscle were used for considering the effect of drugs on the heart i. e. the preparation was used as a model-system of the heart. Urinary bladder with the cholinergic pelvic nerve and ductus deferens with adrenergic nerve were used as model-system for coronary vessels. Three types of coronarodilatators were found. First type blocked all three model-systems (Segontin). Second type decreased the effect of autonomic nerves on smooth muscle and increased the effect on striated muscle (Persantin, Isoptin and Aminophylline). Third type decreased only smooth muscle that contracted on cholinergic nerve stimulation (Sodium nitrite and ATP). Strophantin and deslanoside modified the effect of nerve stimulation on three preparations.
Copyright (c) 2026 Seid Huković, Fahrudin Rustambegović, Nurudin Numić https://creativecommons.org/licenses/by/4.0/
Approach to the Study of Inapparent Form of Relapses in Typhus Fever
To test the hypothesis of possible existence of inapparent serorecidives in typhus fever, the study area must have the following conditions: - at least some part population must be infested by body lice, - there must be some fresh focci of typhus fever or at least some recent cases, - there must be previous cases of Brill-Zinsser’s disease as well of typhus fever, - the study area must be under careful surveillance to ensure that manifest cases of typhus fever (very probable reinfections) are not declared as occult serorecidives. Such a study area has been found in the villages along the range of the mountain of Vlašić (Travnik). C. F. test made on 24 bloods taken from children up to 7 years old as well as from 41 bloods from wood workers resulted in positive residual titer in 1 child and 16 workers. C. F. test as well F. A. test (indirect fluorescent antibody technique) were performed on bloods from 12 patients having had Brill-Zinsser’s disease and 10 patients with previous typhus fever. From each patient 3 blood samples were taken 4 months apart and none revealed a rise of C. F. and F. A. titters. On the basis of this preliminary studies the above-mentioned hypothesis couldn’t be proved.
Copyright (c) 2026 Jakob A. Gaon, Zlatko R. Puvačić https://creativecommons.org/licenses/by/4.0/
Thromboangiitis Obliterans and Results Obtained by Pyretotherapy Using Malaria
Thromboangiitis obliterans (Buerger’s Disease) is considered to be a clinical and pathologic entity with sufficient characteristic diagnostic criteria to enable the differentiation from other peripheral vascular diseases. In the last 3 years 114 patients were diagnosed and treated in the Institute of Dermatology having Buerger’s Disease. The most of them were men (106) and the first clinical manifestation of the disease appeared mainly up to the age of 35 years (80,9%). The youngest patient being 18 years old. Regarding the occupation of the patients 60% of them were physical workers exposed to various environmental factors. A great number of them were common unqualified workers doing outer heavy physical work (loggers, Street cleaners, construction workers etc.) and a small number were administrative employees (13%). The great majority of the patients are or have been heavy smokers (95,6%) what is considered as a most important factor in the pathogenesis of Buerger’s Disease. In patients who have continued to smoke in spite of treatment the disease in the rule has progressed and in almost all patients in whom after successful treatment lesions recurred were patients who whether did not stop smoking at all or started to smoke again. For routine treatment of Thromboangiitis Obliterans in the rule a conservative attitude was adopted and only in quite exceptional instances surgical procedures have been applied. Generally, besides the usual conservative therapeutic procedures used in the treatment of thromboangiitis obliterans (anticoagulant therapy, vasodilating drugs, vitamin E, local treatment of gangrene, complete abstinence from smoking) pyretotherapy by inoculation with malaria tertiana (Plasmodium vivax) was applied in addition. Some of the patients (32) were treated with malaria only. The inoculation was carried out by injecting malarial blood (i. m. or i. v.) from patient to patient. Usually it was allowed in one course of malarial treatment t6 advance 5—7 fever attacks reaching in total about 40 hours of raised temperature of 38,5° C or more. The termination of the infection was achieved by administration od Resochin and Primaquine. This kind of treatment was applied in 114 patients — 90 of them were previous' treated by various drugs or surgical procedures (sympathectomy or ganglienectomy in 41 patients, amputation in 22) without satisfactory results. The most of them were in the Progressive stage (stage IV) of the disease. Already during the fever attacks in most instances certain improvements could be noticed and in follow up during the period from 12—36 months 66,67% of patients were improved. In patients with ulcers or gangrene healing could be achieved in 63%. Recurrence of the disease usually with Progressive ulcerative gangrenous lesions was observed during the observation period in 26,3% whereas such episodes before treatment were occurring in 50% of patients. In almost all such cases the patients started to smoke again or had encountered an exogen trauma. Sometimes a heavy psychogenic insult could be considered as the course of the recurrent episode. Of all 114-malaria treated patient’s amputation was carried out in 4 only predominantly because the patient was not able to tolerate the pains. In general, it could be concluded that pyretotherapy by malaria inoculation has a very favourable effect in treatment and arresting the progression of Buerger’s Disease.
Copyright (c) 2026 Ernest I. Grin, Luka Pirnat, Efrosina Dimitrijević, Ljubo Šimić https://creativecommons.org/licenses/by/4.0/
The Attempt of Specific Therapy of Botulinus Intoxication and Its Relation to the Antitoxic Serum
Mice intoxicated with botulinus were administered combination of antitoxic serum and various substances, and the effect were observed. Substances that had already been proved to increase significantly the lifespan of intoxicated mice have been put to test, as well as some other substances which are known to be capable of re-starting acetylcholine release that was blocked by botulinum toxin. The combination of serum with these substances was administered at the beginning and in the later stage of intoxication. It was shown that above mentioned substances, when combined, did not increase the percentage of survival move than each substance alone. The discussion stressed the point that detoxication of botulism with antitoxic serum is not specific therapy because its effect is limited to the early stage of intoxication. New ways of searching for efficient therapy of botulism were indicated in the discussion.
Copyright (c) 2026 Kemo Valjevac, Pavel Štern https://creativecommons.org/licenses/by/4.0/
The Influence of 1, 1, 1-Trichloro-2, 2-BIS (P-Chlorophenyl) Ethan (DDT) Upon the Muscle Distrophv in Rats
It has been shown that muscles of posterior extremities of rats with muscular dystrophy caused by Selye’s method regain nearly normal weight after administration of DDT. Histologic changes (atrophy, degeneration, necrosis) in muscles treated with DDT are smaller than in control animals.
Copyright (c) 2026 Pavel Štern, Edita Gmaz-Nikulin https://creativecommons.org/licenses/by/4.0/
Naš eksperimentalni doprinos proučavanju tuberkuloze
Copyright (c) 2026 Milutin Đurišić https://creativecommons.org/licenses/by/4.0/
Sedam negativnih pokušaja terapije vezikalne hematurije goveda
Copyright (c) 2026 Josip Ježić, Mehmedalija Ibrović https://creativecommons.org/licenses/by/4.0/
Hemolitičko-uremički syndrom — ozbiljna teškoća uspješne terapije vezikalne hematurije goveda
Izazivanje model-oboljenja i ispitivanje konzekutivnih promjena serotonina i monoaminooksidaze u raznim tkivima
Copyright (c) 2026 Seid Huković https://creativecommons.org/licenses/by/4.0/
The Influence of Mediators in the Growth of Malignant Tumors
5 different pharmacologic groups capable of decreasing or increasing transmitter substances an organism (noradrenalin, adrenalin, serotonin, histamine, acetylcholine) were examined, besides amino acids glycine and GABA were also examined. These substances were administrated to mice with carcinoma, sarcoma or leukaemia it was shown that there is probably correlation between the quantity of adrenaline and growth of tumour. It was also shown that glycine inhibits growth of some malignant tumours.
Copyright (c) 2026 Pavel Štern https://creativecommons.org/licenses/by/4.0/
The Effect of Nucleotides, Autocoides and Neurotransmittors Upon Smooth Muscle of Blood Vesels and Lungs (In Situ and in Vitro)
Acetylcholine, histamine and adenosine triphosphate induce increase of blood pressure in pulmonary artery and decrease in femoral artery of anesthetized dogs. Adrenaline and serotonin increased the pulmonal arterial blood pressure. The effect of ADP, and AMP was insignificant. The relaxation and decrease of the response of isolated frog’s lung induced adrenaline, serotonin, AMP and adenosine. The spasm of the lungs smooth muscle was found after acetylcholine, histamine, ADP and ATP. The comparison of the results got i n vitro with then in situ suggests conclusion that endogenic substances which induce relaxation of isolated lungs decrease the blood pressure in pulmonary artery. Direct effect of different active agents is rather important in regulation of respiratory movement.
Copyright (c) 2026 Sead Brkić, Muzafer Mujić, Seid Huković, Husein Kulenović https://creativecommons.org/licenses/by/4.0/
Acelularnošću uzrokovano ubrzanje metabolizma — esencijalna karakteristika maligne stanice
Copyright (c) 2026 Josip Ježić https://creativecommons.org/licenses/by/4.0/
The differences in enzyme activity between eccrine and apocrine glands have been often used in investigations of the origin and differentiation of skin tumours (10, 11, 12, 13, 17, 22, 23, 24). Result reported in the literature regarding the amount and distribution of the enzymes in sweat glands (1, 3, 4, 5, 6, 7, 8, 9, 12, 14, 15, 18, 19, 24, 25) are often controversial because of its regional, developmental and physiological variations. Besides, different histochemical methods used as well as different interpretations of obtained reactions make the problem even more difficult. In the present study, adult axillary skin was investigated particularly toward enzymes which are claimed to be a reliable basis for sweat gland differentiation.
Copyright (c) 2026 Melita Švob https://creativecommons.org/licenses/by/4.0/
Drugi prilog izučavanju radioaktivnih zračenja u etiopatogenezi vezikalne hematurije goveda
Copyright (c) 2026 Josip Ježić, Zvonko Knežević https://creativecommons.org/licenses/by/4.0/
Different Influence of Anticholinesterase Poissons Given on Serose or Mucose Side of Isolated Innervated Stomach
Spastic poisons applied on serose side of isolated rat's stomach produce the increase of the effect of cholinergic nerves stimulation. Vice versa the anticholinesterases applied on mucose side do not have spastic effect but even produce relaxation. It is suggested that the receptor for excitatory reaction could be near the serose and the receptors for relaxation near mucose. The mucose and other parts of wall of the rats stomach are impermeable for vegetative poisons in vitro.
Copyright (c) 2026 Seid Huković, Kamenko Brankov, Svetozar Miletić https://creativecommons.org/licenses/by/4.0/
Study of C. F. Antibodies Against R. Prowazeki in the Population of Bosnia and Herzegovina
In Bosnia and Herzegovina 1041 human sera taken in different villages was used to determine prevalence-rate of C. F. antibodies against R. prowazeki, according age, sex and ethnic groups. It was found that 11,56% males and 17,11% females have C. F. antibodies with titters 1:8 and more. In a similar study performed in 1954 higher C. F. prevalence rate was found in moslem population. In this study wasn't proved any statistical difference between moslem and non-moslem population. In children up to 10 years of age 2,51% was found with C. F. antibodies although the health Service didn’t record in the same villages any cases of typhus fever. In Bosnia still occurs very rarely primary classical typhus among small children and much more often cases of recrudescent typhus fever. In regard to a low rate of infestation of rural population in Bosnia with body lice and very low fresh human infections with R. provvazeki the author emphasizes that is now the most favourable moment for republican program for the final eradication of lousiness and classical typhus fever.
Copyright (c) 2026 Jakob A. Gaon https://creativecommons.org/licenses/by/4.0/
Erythrophagocytosis in Dermatitis Ulcerosa (Pyoderma Gangrenosum)
There are various names to be found in the medical literature for the same cutaneous disorder with its distinctive morphologic features well recognized as an clinical entity and at present mostly called Pyoderma gangrenosum (Brunsting, Goeakerman a. O’Leary6) or Dermatitis ulcerosa (Kresbach”)- In this report the term Dermatitis ulcerosa is suggested as the most appropriate since it does not prejudice the etiopatogenecity of the disease which is not known and there is very low indication that the pyogenic infection is the main etiological factor. Two female patients with classical clinical picture of Dermatitis ulcerosa and typical course of the disease were studied to broaden the concept of this rather vague disorder. One of the patients had associated colitis ulcerosa and visceral candidiasis (candida albicans). To our experience this condition could not be considered as necessarily related to dermatitis ulcerosa and even less caused by it. In the other patient no such or any other associated disorder were found. The very extensive laboratory investigations could not reveal any conclusive finding which could be regarded as specific for dermatitis ulcerosa. Also, the histopathology demonstrated only the usually structures suggestive of the diagnosis. Antibiotic treatment remained ineffective. However, steroids brought about complete involution of the lesions. Also, in our patients the initial lesion was sterile showing in the native preparation besides cellular elements (macrophages and other) free lying elastic fibres from the destroyed tissue (illustrated by fig. 4). It is interesting to note that the lesions in dermatitis ulcerosa — contrary to the normal wound healing — begun to heal (epithelise) in the rule in the central part of the lesion progressing to the periphery though sometimes the borders of the lesion are still in active extension. The extension of the lesion or recurrences after complete healing \vas always going from the border to further periphery and never back to the area of the previously ulcerated skin this circumstance may indicate that an immunological mechanism might be involved (skin specific hypersensitivity). The most peculiar findings in the report relate to the phenomenon of erythrophagocytosis which could be seen in the native preparations and Giemsa strained smears in material taken from the active lesions particularly from the peripheral borders in extension. The macrophages seen in this material may contain numerous erythrocytes which appear to be intact and have been phagocytised whole rather than after rupture. Sometimes there could be observed in the native preparation erythrophagocytosis at different stages of the active process of phagocytosis as adherence of erythrocytes (occasionally becoming elongated) to the phagocyte, then becoming surrounded and drown into the macrophage (illustrated by fig. 5—10). In peripheral blood smears erythrophagocytosis could not be observed in the reported patients. This phenomenon which to our knowledge has not previously been recorded in dermatitis ulcerosa (Pyoderma gangrenosum and other denotation for the same disorder) is suggested to be a process of tissue mediated immunological mechanism. In discussing the presumptive etiopathogenetic factors of dermatitis ulcerosa an immunological mechanism seems to be indicated although no sufficient proved evidence as reflected by altered immunoglobulin classes or respective antibodies is at present available.
Copyright (c) 2026 Ernest I. Grin, Vera Tadić-Tigerman https://creativecommons.org/licenses/by/4.0/
Prolegomena i paralegomena o lokalizaciji dermatopatija
Copyright (c) 2026 Fran Kogoj https://creativecommons.org/licenses/by/4.0/
Novija saznanja o patogcnezi i savremenoj terapiji gnojnog meningitisa
Copyright (c) 2026 Kosta Todorović https://creativecommons.org/licenses/by/4.0/