Pharmacological Methods in Toxicology on the Isolated Innervated Organs From the Mouth
DOI:
https://doi.org/10.5644/Radovi.302Abstract
Isolated and innervated organs from the mouth were prepared. They were striated muscles from the tongue and from the farinx. They were prepared with the motor nerve and set up in an isolated organ bath. The induced contractions were recorded and the xenobiotics-ecotoxins were injected. The toxins were benzene and derivatives, trichlorethylene, mercury and lead. It was found that they increase
the effect of nerve stimulation, they increased the height of induced contractions, depending on concentration. The explanation of the effect was that they inhibit enzymes and they free the neurotransmitters.
References
Bielscn, J. B. and Andcrsen, O.: Effects of Dose on Intestinal Absorption and Relative Organ Distribution. Toxicology, 59, 1—10, 1989.
Cooney, G. H., Bell, A., McBride, W., and Čarter, C.: Low-Level Exposures to Lead: The Svdney Lead Sttidy. Dev. Med. Child Ncurol. 31, 640—649, 1989.
Cory-Slechta, D. A., Weiss, B. and Cox, C.: Tissue Distribution of Pb in Adult vs. Old Rats: A Pilot Study. Toxicology, 59, 139—150, 1989.
Crebelli, R. and Carera, A.: Genetic Toxicology of I, I, 2, — trichloroethylene. Mutat. Res. 221, 11—37, 1989.
Da Silva, C., Fan, X. and Castagna, M.: Benzene-Mediated Protein Kinase C Activation. Environ. Health Perspect. 82, 91—95, 1989.
Droz, P. O., W u, M. M. and Cumberland, W. G.: Variability in Biological Monitoring of Organic Solvent Exposure. II. Application of a Population Physiological Model. Br. J. Ind. Med., 46, 547—558, 1989.
Gelbier, S. and Ingram, J.: Possible Foetotoxic Effects of Mercury Vapour: A Case Report. Public Health, 103, 35—40, 1989.
Hare, M. F., Minnema, D. J., Cooper, G. P. and Michaelson, I. A.: Effects of Mercuric Chloriđe on (3H) dopamine Release From Rat Brain Striatal Synaptosomes. Toxicol. Appl. Pharmacol. 99, 266—275, 1989.
Mclntosh, M. J. Meredith, P. A., Moore, M. R. and Goldberg, A.: Action of Lead on Neurotransmission in Rats. Xenobiotica, 19, 101—113, 1989.
Ma 1 toni, C., Ciliberti, A., Cotti, G. et al.: Benzene, an Experiniental Multipotential Carcinogen: Results of the Long-Term Bioassays Perfornied at the Bologna Institute of Oncology. Environ. Health Perspect, 82, 109—124, 1989.
Opdam, J. J. G. and S molder s, J. F. J.: A Method for the Retrospective Estimation of the Individual Respiratory Intake of a Highly and a Poorly Metabolising Solvent During Rest and Physical Exercise. Br. J. Ind. Med., 46, 250—260, 1989.
Oudar, P., Caillard, L. and Fillion, G.: The Effects of Inorganic Lead on the Spontaneous and Potassium-Evoked Release of 3H-5-HT from Rat Cortical Synaptosome Interaction with Calcium. Pharmacol. Toxicol.
64, 459—463, 1989.
Rius, R. A., Govoni, S., Bergamaschi, S. et al.: Mechanisms of the Effect of Lead on Brain Neurotransmission: A Calcium Mediated Action. Sci. Total Environ. 71, 441—448, 1988.
Scarlett, J. M., Gutenmann, W. H. and Lisk, D. J.: A Study of Mercury in the Hair of Dentists and Dental — Related Professionals in 1985 and Subcohort Comparasion of 1972 and 1985 Mercury Hair Levels. Toxicol. Environ Health 25, 373—381, 1988.
Zbinden, G. and Gross, F.: Pharmacological Methods in Toxicology, Pergamon Press, Oxford, 1979.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Elvedina Kapić
This work is licensed under a Creative Commons Attribution 4.0 International License.
