Autobioassay in the Quality Control of Drugs
DOI:
https://doi.org/10.5644/Radovi.308Abstract
Autobioassay can be used in analyses of drug effects in two ways. It can be used as an instrument or as a place of drug activity. In the first case it can replace a lacking apparatus and in the second case it can show the effect of drugs that could not otherwise be recorded. By autobioassay on isolated organs an analysis of exogenously added drugs is meant with a simultaneous stimulation of pertaining motor nerves. By applying autobioassay with isolated tissues vivisection can be avoided, especially the one done by repetition, to satisfy certain standards. The described IIO can be used in analyses of neurotransmission and cotransmission. Autobioassay can be used in the quality control of drug effects.
References
Bartfai, T., Iverfeldt, K. and Fisone, G.: Regulation of the Release of Coexisting Neurotransmitters, Ann. Rev. Pharmacol. Toxicol, 28, 1988, 285—310.
Burnstock, G.: Co-Transmission, The Fifth Heymans Memorial Lecture s. 138—164, Heymans Fondation, Ghent, Belgium, 1990.
Campbell, G.: Cotransmission, Ann. rev. pharmacol. toxicol. 27, 1987, 51—70.
Furness, J. B., Morris, J. L., Gibbins, I. L. and Costa, M.: Chemical Codings of Neuron and Neurochemical Transmission, Ann. rev. pharmacol. toxicol. 29, 1989, 289—306.
Hokfelt, T., Fuxe, K. and Pernow, B.: Coexistence of Neronal Messengers: A New Priciple in Chemical Transmission. Progress in Brain Research. vol. 68, Elsevier, Amsterdam, 1986.
Holzer, P.: M.oeglichkeiten und Graenzen der Methodikisolierte Organe. Abfalle fuer die Forschung. Organe aus dem Schlachthof. U Lembeck, F. Altemativen zum Tierversuch, 1988, s. 81—87.
Huković, S.: Prednosti biološkog metoda istraživanja u farmakologiji, ANUBiH, Posebna izdanja, 51, 1980, 7—41.
Huković, S.: Izolirani i inervirani organi kao poseban metod u framakologiji, ANUBiH, Posebna izdanja, 51, 1980, 11—31.
Huković, S. i Potkonjak, D.: Kvalitet u istraživanju lijekova, ANUBiH, Radovi, 1991.
Kupfermann, I.: Functional Studies of Cotransmission, Physiol. Rev. 1990.
Lembeck, F.: Alternativen zum Tierversuch, Thieme, 1988.
Rand, M. J. and Mitchelson, F.: The Guts of the Matter: Contribution of Studies on Smooth Muscle to Discoveries in Pharmacology, Discoveries in Pharmacology, 3, 1986, 19—61.
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