Reversible delayed hypoxic leukoencephalopathy associated with methadone overdose

William D. Freeman, Scott C. Palmer, Michelle L. Freeman, Kevin M. Barrett


A 42-year-old man developed coma and hypoxemic respiratory arrestafter snorting and ingesting methadone and required transient intubationand mechanical ventilation in the emergency department (ED). Hewas given naloxone intravenously, woke up and was extubated.

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