Family Thrombocytopenia Associated With Abnormal Hemoglobin — Variant Strumica
DOI:
https://doi.org/10.5644/Radovi.269Keywords:
Thrombocytopenia, Haemolysis, Reticulocytosis, Abn Hb StrumicaAbstract
In the second generation of a family from Sarajevo (SR of Bosnia and Herzegovina — Yugoslavia) thrombocytopenia was found in three members (a sister and two brothers), with prolonged time of haemorrhage, prolonged generation of thromboplastin with thrombocytes of the diseased. Weak retraction of coagulum and shortened life of thrombocytes. There was no splenomegalia in the same members of this family abnormal haemoglobin (Hb X) or variant STRUMICA was found, in addition to hemolysis, reticulocytcsis, anem a of different degrees and elevated values of free bilirubin.
No chromosome alterations in the cariotype were found and the investigation of the HLA system showed no congruity amongst the HLA systems of the diseased.
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