Investigation of Phagocytary Activity of Reticuloen-Dothelial System by Means of Radioactive Gold Au198 in Experimental Hystamine Shock
DOI:
https://doi.org/10.5644/Radovi.231Abstract
By model of experimental histamine shock upon twenty five rabbits using detection of RES , ,clearance” was determined the phagocytarj' activity of RES (phagocytary index ,,K” and half time of ,,PVE” elimination i.v. taken-in electro-negative colloid solution of radioactive gold Au198). Also, were used the methods for follow-up of capability of maintenance of radioactive isotopes Au198 particles in organs rich with RE-cells (liver, spleen, bone-marrow) in various periods of recovery after histamine liberation.
The investigations have shown that in the observation period beginning from the twentieth minute after histamine liberation up to 48 hours appear marked changes in the function of RES.
At the beginning phase after histamine liberation was established the reduced ability of elimination of taken-in test substance from blood.
Already 6 hours as well as 48 hours the phagocytary activity intensifies. This is confirmed by the values of phagocytary index KP as well as values of half-time elimination ,,PVE” which is 3 or 5 times shorter than in control group. Besides the results of behaviour of phagocytary activity of RES in the recovery period after histamine shock in this work have been studied the tests of activity in a gram of organ sample (liver, spleen and bone-marrow) as well as the activity in a gram of the same organ sample relating to the administered dose.
These findings represent precious explanations of series of morphologic observations in histamine shock and fill in the findings out about its pathogenesis and repercussions.
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