The Quality of Drug Investigation
DOI:
https://doi.org/10.5644/Radovi.307Abstract
In the year of the quality of health care quality of drug research was stressed. One of the first steps in the pharmacological evaluation of substances is in vitro investigation. The isolated organs with extrinsic and intrinsic nerve electrical stimulation could be used to get the results for the first decision about the quality of future drugs. Using the isolated organs with a simultaneous stimulation of their motor nerve, the danger of false-positive or false-negative results could be decreased. It is a danger to accept substance for further investigation or to abandon the substance which could be a useful future drug. The isolated and innervated organs as model-systems could help to make adequate decisions.
References
Black, J. (1986): Basic Drug Research in Universities and Industry. Br. J. cli. n. Phannacol., 22, 58—78.
Bulpitt, C. J. and Fletcher, A. E. (1990): The Measurment of Quality of Life in Hypertnesive Patients: a Practical Approach. Br. J. clin. Pharmacol. 30, 353—365.
Callender, J. S. (1990): Assesment of Quality of Life in the Treatment of Hypertension. Br. J. clim. Pharmacol, 30, 345—351.
Cromie, B. V. (1986): Drug Research and Development in the Pharmaceutical Industrv, 22, 98—158.
Donabedian, A. (1989): Institutional and Professional Responsibilities in Quality Assnrance. Qyality assurance inhelath care, 1, 3—11.
Goodford, P. (1987): Receptor-Based Drug Design. U Rand, M. J. and Raper, C.: Pharmacology, Excerpta Medica, Congres Series, s. 607—614.
Kerlinger, F. N. (1973): Foundation of Behavioural Research. Second Edition, Holt-Saunders International Editions.
McEven, J. (1986): Contribution of universities to drug evaluation. Br. J. Clin. Pharmacol. 22, 156—198.
Palmer, A., Flecher, A., Hamilton, G., Muriss, S. and Bulpitt, C. (1990): A Comparission of Verapamil and Nifedipin on Quality of Life. Br. J. Clin. Pharmacoll. 30, 365—371.
Snell, E. S. (1986): Profitability and Improved Patient Care, Industry’s Viewpoint. Br. J. Clin. Pharmacol, 22, 338—418.
Turner, P. (1986): Profitdbility and Improved Patient Care, Physician's Viewpoint. Br. J. Clin. Pharmacol., 22, 418—458.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Seid Huković, Dubravka Potkonjak
This work is licensed under a Creative Commons Attribution 4.0 International License.
