Non-interventional Pilot Study Evaluating the Efficacy and Safety of Lysozyme-based Therapy in Patients with Noninfectious Sore Throat

Authors

  • Selma Karakaš Public Institution for Occupational Medicine of Sarajevo Canton
  • Dženana Huduti Public Institution for Occupational Medicine of Sarajevo Canton
  • Meliha Mehić Medical Support Unit, Bosnalijek d.d.
  • Aziz Šukalo Strategic Marketing and Market Support Department, Bosnalijek d.d.,
  • Jasna Džananović Jaganjac Scientific Research Unit, Bosnalijek d.d.
  • Amna Tanović Avdić Medical Support Unit, Bosnalijek d.d.
  • Amira Skopljak Public Institution Sarajevo Canton Health Center
  • Azra Dupovac Public Institution Sarajevo Canton Health Center
  • Zehra Sarajlić Sarajevo University Clinical Center
  • Una Glamočlija Scientific Research Unit, Bosnalijek d.d.; Department for Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo; School of Medicine, University of Mostar

DOI:

https://doi.org/10.5644/ama2006-124.364

Keywords:

Lysozyme, Functional, Dysphonia, Professional Exposure, Sore Throat

Abstract

Objective. This study aimed to evaluate the efficacy and safety of lysozyme-based oral antiseptic in the therapy of non-infectious sore throat in teachers.

Materials and Methods. A non-interventional, prospective, pilot study was conducted with two examinations. The first was performed as part of a general medical examination. If a non-infectious sore throat was confirmed by clinical checkup and all other inclusion and non-exclusion criteria confirmed, patients were offered to be enrolled in the study. After signing the informed consent form, patients were advised to use lysozyme-based lozenges, six times a day, for a period of five days. A telephone call follow-up examination was performed within 24 hours from the therapy completion.

Results. This was a pilot study involving 25 adult patients of both genders. Lysozyme-based lozenges showed positive effects in relieving the symptoms of non-infectious sore throat in teachers. At the same time, the lozenges showed excellent tolerability, and no side effects were reported during the study. 92% of patients confirmed they would take the same medicine again due to the same problem. Conclusion. The results of this “proof-of-concept” study indicated that lysozyme-based antiseptic could be effective and safe in the treatment of non-infectious sore throat in teachers and should be further evaluated as treatment option in this condition.

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Published

2022-12-16

How to Cite

Karakaš, S., Huduti, D., Mehić, M., Šukalo, A., Džananović Jaganjac, J., Tanović Avdić, A., Skopljak, A., Dupovac, A., Sarajlić, Z., & Glamočlija, U. (2022). Non-interventional Pilot Study Evaluating the Efficacy and Safety of Lysozyme-based Therapy in Patients with Noninfectious Sore Throat. Acta Medica Academica, 51(1), 1–13. https://doi.org/10.5644/ama2006-124.364

Issue

Section

Clinical Medicine

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